Left-handed people have had a pretty impressive presence in the White House recently, as I noted in a post a couple years ago. In the past quarter-century, only one President (George W. Bush) signed bills with his right hand. George H.W. Bush, Bill Clinton, and Barack Obama are all left-handed. The first left-handed President that we are certain of was Gerald Ford.
You can almost stretch that dominance to Ronald Reagan. Reagan was born as a leftie, but trained as a youngster to use his right hand instead, as many people were back when being left-hand dominant was seen as almost a disability. This makes it tough to figure out exactly which of our more distant Presidents were right- or left-handed. Truman was also supposedly born left-handed. It’s been said that Hoover was left-handed, but every photo that I’ve ever seen has shown him writing with his right hand. James Garfield was ambidextrous and could write with either hand.
An even odder fact than the relatively high number of recent left-handed Presidents: In three of the six Presidential elections in the last 20 years, each major party nominee has been left-handed, including 1992 when all three major candidates — George H.W. Bush, Bill Clinton, and Ross Perot — were lefties.